タイトル | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING. |
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ジャーナル・号・ページ | Nat Commun, Vol. 14, Page 8519-8519, Year 2023 |
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掲載日 | 2022年12月30日 (構造データの登録日) |
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著者 | Hou, M.H. / Wang, Y.C. / Yang, C.S. / Liao, K.F. / Chang, J.W. / Shih, O. / Yeh, Y.Q. / Sriramoju, M.K. / Weng, T.W. / Jeng, U.S. ...Hou, M.H. / Wang, Y.C. / Yang, C.S. / Liao, K.F. / Chang, J.W. / Shih, O. / Yeh, Y.Q. / Sriramoju, M.K. / Weng, T.W. / Jeng, U.S. / Hsu, S.D. / Chen, Y. |
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リンク | Nat Commun / PubMed:38129386 |
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手法 | X線回折 |
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解像度 | 1.462 - 2.73 Å |
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構造データ | PDB-8hwi: Bacterial STING from Larkinella arboricola in complex with 3'3'-c-di-GMP 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å PDB-8hwj: Bacterial STING from Epilithonimonas lactis in complex with 3'3'-c-di-AMP 手法: X-RAY DIFFRACTION / 解像度: 2.553 Å PDB-8hy8: Bacterial STING from Epilithonimonas lactis 手法: X-RAY DIFFRACTION / 解像度: 2.568 Å PDB-8hy9: Bacterial STING from Riemerella anatipestifer in complex with 3'3'-c-di-GMP 手法: X-RAY DIFFRACTION / 解像度: 1.462 Å PDB-8hyn: Bacterial STING from Riemerella anatipestifer 手法: X-RAY DIFFRACTION / 解像度: 2.089 Å |
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化合物 | ChemComp-C2E: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) / c-di-GMP
ChemComp-2BA: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 / c-di-AMP
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由来 | larkinella arboricola (バクテリア) epilithonimonas lactis (バクテリア) riemerella anatipestifer yb2 (バクテリア)
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キーワード | SIGNALING PROTEIN / CD-NTase-associated protein 12 |
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