EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
ジャーナル・号・ページ	Biochemistry, Year 2024
掲載日	2023年3月20日 (構造データの登録日)
著者	Katinas, J.M. / Nayeen, M.J. / Schneider, M. / Shah, K. / Fifer, A.N. / Klapper, L.M. / Sharma, A. / Thalluri, K. / Van Nieuwenhze, M.S. / Hou, Z. ...Katinas, J.M. / Nayeen, M.J. / Schneider, M. / Shah, K. / Fifer, A.N. / Klapper, L.M. / Sharma, A. / Thalluri, K. / Van Nieuwenhze, M.S. / Hou, Z. / Gangjee, A. / Matherly, L.H. / Dann 3rd, C.E.
リンク	Biochemistry / PubMed:38324671
手法	X線回折
解像度	2.38 - 3.06 Å
構造データ	PDB-8gks: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF291 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.99 Å PDB-8gkt: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF320 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.64 Å PDB-8gku: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF355 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.06 Å PDB-8gkw: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF359 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-8gky: Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and AGF359 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.77 Å PDB-8gkz: Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and AGF362 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-8t4o: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347 inhibitor with no glutamate 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-8t4p: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and di-glutamate AGF347 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.801 Å PDB-8tlc: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å
化合物	ChemComp-GLY: GLYCINE / グリシン ChemComp-Y6U: N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamic acid / N-[4-[3-[(2-アミノ-3,4-ジヒドロ-4-オキソ-5H-ピロロ[3,2-d]ピリミジン)-5-イル]プロピ(以下略) ChemComp-PLP: PYRIDOXAL-5'-PHOSPHATE / ピリドキサ-ル5′-りん酸 ChemComp-HOH: WATER ChemComp-PLG: N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE] ChemComp-Y7L: N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid 化合物画像なし ChemComp-ZV1: Unknown entry 化合物画像なし ChemComp-ZVR: Unknown entry ChemComp-Y72: N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid 化合物画像なし ChemComp-Y5C: Unknown entry 化合物画像なし ChemComp-Y5Z: Unknown entry 化合物画像なし ChemComp-I6I: Unknown entry
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/INHIBITOR / SHMT2 / tetramer / glycine synthesis / inhibitor / TRANSFERASE / TRANSFERASE-INHIBITOR complex / SHMT2 mutant / Mitochondrial / one-carbon metabolism / polyglutamate / complex / serine and glycine metabolism