タイトル | X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences. |
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ジャーナル・号・ページ | Acs Bio Med Chem Au, Vol. 3, Page 335-348, Year 2023 |
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掲載日 | 2022年8月31日 (構造データの登録日) |
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著者 | Ogbonna, E.N. / Paul, A. / Farahat, A.A. / Terrell, J.R. / Mineva, E. / Ogbonna, V. / Boykin, D.W. / Wilson, W.D. |
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リンク | Acs Bio Med Chem Au / PubMed:37599788 |
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手法 | X線回折 |
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解像度 | 1.08 - 2.23 Å |
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構造データ | PDB-8ec1: 5'-CGCGAATTCGCG-3' and benzimidazole diamidine (DB1476) comlpex with ligand orientation I 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-8ed6: 5'-CGCGAATTCGCG-3' and benzimidazole diamidine (DB1476) complex with ligand orientation II 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-8eda: An alternating AT dodecamer benzimidazole (DB1476) complex 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-8edb: 5'-CGCGAATTCGCG-3' and an AT-specific binder (DB1884) complex 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-8f1s: A benzimidazole (DB1476) sequence-specific recognition of 5'-CGCAAAAAAGCG-3' in A-orientation 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8f1v: A benzimidazole (DB1476) sequence-specific recognition of 5'-CGCAAAAAAGCG-3' in B-orientation 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8f20: Structure of an A-tract B-DNA Dodecamer: 5'-CGCAAAAAAGCG-3 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-8f2w: Structure of a B-Form Dodecamer: 5'-CGCGAATTCGCG-3 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-8f2y: Structure of an alternating AT dodecamer: 5'-CGCGATATCGCG-3 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-8f94: Structure of an alternating AT 16-mer: 5'-GCTGGATATATCCAGC-3 手法: X-RAY DIFFRACTION / 解像度: 1.08 Å PDB-8fb4: Structure of an alternating AT 16-mer bound by diamidine DB1476: 5'-GCTGGATATATCCAGC-3 手法: X-RAY DIFFRACTION / 解像度: 1.49 Å PDB-8fdp: The native structure of a dodecamer: 5'-CGCAAATTTGCG-3 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-8fdq: An AT-specific DNA 5-CGCAAATTTCGC-3' with benzimidazole (DB1476) complex 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-8fdr: Structure of a dodecamer complex: 5'-CGCGAAAAGCCG-3-DB1476 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å |
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化合物 | ChemComp-WFB: 4,4'-(1H-benzimidazole-2,6-diyl)di(benzene-1-carboximidamide)
ChemComp-884: 4,4'-(1H-indole-2,6-diyl)dibenzenecarboximidamide
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由来 | - homo (哺乳類)
- homo sapiens (ヒト)
- dna molecule (その他)
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キーワード | DNA / B-DNA / MINOR GROOVE / SMALL MOLECULE / Minor groove binder / sequence recognition / AT sequence |
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