タイトル | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. |
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ジャーナル・号・ページ | Biochemistry, Vol. 62, Page 923-933, Year 2023 |
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掲載日 | 2022年7月22日 (構造データの登録日) |
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著者 | Ratia, K.M. / Shen, Z. / Gordon-Blake, J. / Lee, H. / Laham, M.S. / Krider, I.S. / Christie, N. / Ackerman-Berrier, M. / Penton, C. / Knowles, N.G. ...Ratia, K.M. / Shen, Z. / Gordon-Blake, J. / Lee, H. / Laham, M.S. / Krider, I.S. / Christie, N. / Ackerman-Berrier, M. / Penton, C. / Knowles, N.G. / Musku, S.R. / Fu, J. / Velma, G.R. / Xiong, R. / Thatcher, G.R.J. |
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リンク | Biochemistry / PubMed:36746631 |
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手法 | X線回折 |
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解像度 | 1.321 - 2.2 Å |
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構造データ | PDB-8dsc: Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R 手法: X-RAY DIFFRACTION / 解像度: 1.321 Å PDB-8dsd: Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-S 手法: X-RAY DIFFRACTION / 解像度: 1.429 Å PDB-8dse: Human NAMPT in complex with substrate NAM and activator quercitrin 手法: X-RAY DIFFRACTION / 解像度: 1.428 Å PDB-8dsh: Human NAMPT in complex with quercitrin and AMPcP 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8dsi: Human NAMPT in complex with substrate NAM 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-8dtj: Human NAMPT in complex with small molecule activator ZN-43-S 手法: X-RAY DIFFRACTION / 解像度: 2.118 Å |
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化合物 | ChemComp-TIE: (3R)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide
ChemComp-TIW: (3S)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide
ChemComp-QCT: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside / クエルシトリン
ChemComp-TKF: (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / NAD biosynthesis enzyme:activator complex |
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