タイトル | Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae alpha-Carbonic Anhydrase. |
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ジャーナル・号・ページ | Acs Med. Chem. Lett., Vol. 14, Page 103-109, Year 2023 |
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掲載日 | 2022年7月15日 (構造データの登録日) |
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著者 | Marapaka, A.K. / Nocentini, A. / Youse, M.S. / An, W. / Holly, K.J. / Das, C. / Yadav, R. / Seleem, M.N. / Supuran, C.T. / Flaherty, D.P. |
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リンク | Acs Med. Chem. Lett. / PubMed:36655133 |
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手法 | X線回折 |
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解像度 | 2.15 - 2.81 Å |
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構造データ | PDB-8dpc: Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-8dqf: Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-8dr2: Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with 2-cyclohexyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide 手法: X-RAY DIFFRACTION / 解像度: 2.81 Å PDB-8drb: Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with 3-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide 手法: X-RAY DIFFRACTION / 解像度: 2.59 Å PDB-8dyq: Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with Acetazolamide 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å |
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化合物 | ChemComp-VGV: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide
ChemComp-TE3: 2-cyclohexyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
ChemComp-TBW: 3-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide
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由来 | - neisseria gonorrhoeae (淋菌)
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キーワード | LYASE / Carbonic anhydrase / Neisseria gonorrhoeae / Acetazolamide |
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