タイトル | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. |
---|
ジャーナル・号・ページ | Acs Med. Chem. Lett., Vol. 13, Page 1500-1509, Year 2022 |
---|
掲載日 | 2022年2月10日 (構造データの登録日) |
---|
著者 | Nai, F. / Nachawati, R. / Zalesak, F. / Wang, X. / Li, Y. / Caflisch, A. |
---|
リンク | Acs Med. Chem. Lett. / PubMed:36110386 |
---|
手法 | X線回折 |
---|
解像度 | 1.7 - 2.01 Å |
---|
構造データ | PDB-7r5f: Crystal structure of YTHDF2 with compound YLI_DF_012 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7r5l: Crystal structure of YTHDF2 with compound YLI_DC1_015 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7r5w: Crystal structure of YTHDF2 with compound YLI_DF_029 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7ywb: Crystal structure of YTHDF2 in complex with N6-Methyladenine 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-7yx6: Crystal structure of YTHDF2 with compound YLI_DF_027 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7yxe: Crystal structure of YTHDF2 with compound ZA_143 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-7z26: Crystal structure of YTHDF2 YTH domain in complex with m6A RNA 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7z4u: Crystal structure of YTHDF2 with compound YLI_DF_028 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å PDB-7z54: Crystal structure of YTHDF2 with compound YLI_DC1_006 手法: X-RAY DIFFRACTION / 解像度: 1.82 Å PDB-7z5m: Crystal structure of YTHDF2 with compound YLI_DC1_008 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7z7b: Crystal structure of YTHDF2 with compound YLI_DC1_003 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7z7f: Crystal structure of YTHDF2 with compound YLI_DC1_005 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7z8p: Crystal structure of YTHDF2 with compound ZA_166 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-7z8w: Crystal structure of YTHDF2 with compound YLI_DC1_018 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7z8x: Crystal structure of YTHDF2 with compound YLI_DC1_017 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-7z92: Crystal structure of YTHDF2 with compound YLI_DF_024 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-7z93: Crystal structure of YTHDF2 with compound YLI_DF_022 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-7zg4: Crystal structure of YTHDF2 with compound YLI_DF_042 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å |
---|
化合物 | ChemComp-I82: ~{N}-methyl-3-phenyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChemComp-FIQ: 6-cyclopropyl-3-methyl-1H-pyrimidine-2,4-dione
ChemComp-5ZK: ~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChemComp-IF3: ~{N}2,~{N}6,9-trimethylpurine-2,6-diamine
ChemComp-IFZ: 3-bromanyl-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChemComp-IHR: ~{N}-cyclopropyl-3-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChemComp-IGT: 5-azanyl-3,6-dimethyl-1H-pyrimidine-2,4-dione
ChemComp-IHF: 5-azanyl-6-ethyl-1H-pyrimidine-2,4-dione
|
---|
由来 | homo sapiens (ヒト)
|
---|
キーワード | RNA BINDING PROTEIN / epitranscriptomic reader / m6A reader / Epitranscriptomic reader m6A reader |
---|