タイトル | Structure-based rational design of a short-chain dehydrogenase/reductase for improving activity toward mycotoxin patulin. |
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ジャーナル・号・ページ | Int. J. Biol. Macromol., Vol. 222, Page 421-428, Year 2022 |
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掲載日 | 2022年5月26日 (構造データの登録日) |
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著者 | Dai, L. / Li, H. / Huang, J.W. / Hu, Y. / He, M. / Yang, Y. / Min, J. / Guo, R.T. / Chen, C.C. |
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リンク | Int. J. Biol. Macromol. / PubMed:36176222 |
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手法 | X線回折 |
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解像度 | 1.98 - 2.31 Å |
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構造データ | PDB-7xwh: structure of patulin-detoxifying enzyme with NADP+ 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-7xwi: structure of patulin-detoxifying enzyme with NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-7xwj: structure of patulin-detoxifying enzyme Y155F with NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-7xwk: structure of patulin-detoxifying enzyme Y155F with NADPH and substrate 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-7xwl: structure of patulin-detoxifying enzyme Y155F/V187F with NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-7xwm: structure of patulin-detoxifying enzyme Y155F/V187K with NADPH 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-7xwn: structure of patulin-detoxifying enzyme Y155F/V187K with NADPH and substrate 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-NAP: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
ChemComp-NDP: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / NADPH
ChemComp-I8L: (4~{S})-4-oxidanyl-4,6-dihydrofuro[3,2-c]pyran-2-one
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由来 | meyerozyma guilliermondii (菌類)
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キーワード | OXIDOREDUCTASE / dehydrogenases/reductase / patulin-detoxifying enzyme |
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