EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins.
ジャーナル・号・ページ	Cell Res, Vol. 32, Issue 7, Page 609-620, Year 2022
掲載日	2022年5月31日
著者	Youwei Xu / Canrong Wu / Xiaodan Cao / Chunyin Gu / Heng Liu / Mengting Jiang / Xiaoxi Wang / Qingning Yuan / Kai Wu / Jia Liu / Deyi Wang / Xianqing He / Xueping Wang / Su-Jun Deng / H Eric Xu / Wanchao Yin /
PubMed 要旨	The Omicron BA.2 variant has become a dominant infective strain worldwide. Receptor binding studies show that the Omicron BA.2 spike trimer exhibits 11-fold and 2-fold higher potency in binding to ...The Omicron BA.2 variant has become a dominant infective strain worldwide. Receptor binding studies show that the Omicron BA.2 spike trimer exhibits 11-fold and 2-fold higher potency in binding to human ACE2 than the spike trimer from the wildtype (WT) and Omicron BA.1 strains. The structure of the BA.2 spike trimer complexed with human ACE2 reveals that all three receptor-binding domains (RBDs) in the spike trimer are in open conformation, ready for ACE2 binding, thus providing a basis for the increased infectivity of the BA.2 strain. JMB2002, a therapeutic antibody that was shown to efficiently inhibit Omicron BA.1, also shows potent neutralization activities against Omicron BA.2. In addition, both BA.1 and BA.2 spike trimers are able to bind to mouse ACE2 with high potency. In contrast, the WT spike trimer binds well to cat ACE2 but not to mouse ACE2. The structures of both BA.1 and BA.2 spike trimer bound to mouse ACE2 reveal the basis for their high affinity interactions. Together, these results suggest a possible evolution pathway for Omicron BA.1 and BA.2 variants via a human-cat-mouse-human circle, which could have important implications in establishing an effective strategy for combating SARS-CoV-2 viral infections.
リンク	Cell Res / PubMed:35641567 / PubMed Central
手法	EM (単粒子)
解像度	2.6 - 3.48 Å
構造データ	33336 7xo4 EMDB-33336, PDB-7xo4: SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with two mouse ACE2 Bound 手法: EM (単粒子) / 解像度: 3.24 Å 33337 7xo5 EMDB-33337, PDB-7xo5: SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with one mouse ACE2 Bound 手法: EM (単粒子) / 解像度: 3.13 Å 33338 7xo6 EMDB-33338, PDB-7xo6: SARS-CoV-2 Omicron BA.1 Variant RBD with mouse ACE2 Bound 手法: EM (単粒子) / 解像度: 2.6 Å 33339 7xo7 EMDB-33339, PDB-7xo7: SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two human ACE2 Bound 手法: EM (単粒子) / 解像度: 3.38 Å 33340 7xo8 EMDB-33340, PDB-7xo8: SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three human ACE2 Bound 手法: EM (単粒子) / 解像度: 3.48 Å 33341 7xo9 EMDB-33341, PDB-7xo9: SARS-CoV-2 Omicron BA.2 Variant RBD complexed with human ACE2 手法: EM (単粒子) / 解像度: 3.0 Å 33342 7xoa EMDB-33342, PDB-7xoa: SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with one mouse ACE2 Bound 手法: EM (単粒子) / 解像度: 3.2 Å 33343 7xob EMDB-33343, PDB-7xob: SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two mouse ACE2 Bound 手法: EM (単粒子) / 解像度: 3.3 Å 33344 7xoc EMDB-33344, PDB-7xoc: SARS-CoV-2 Omicron BA.2 Variant RBD complexed with mouse ACE2 手法: EM (単粒子) / 解像度: 3.0 Å 33345 7xod EMDB-33345, PDB-7xod: SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound 手法: EM (単粒子) / 解像度: 3.27 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン ChemComp-ZN: Unknown entry ChemComp-CL: Unknown entry / クロリド
由来	severe acute respiratory syndrome coronavirus 2 (ウイルス) mus musculus (ハツカネズミ) homo sapiens (ヒト) lama glama (ラマ)
キーワード	VIRAL PROTEIN / SARS-CoV-2 / Omicron / Spike / mouse ACE2 / VIRAL PROTEIN/HYDROLASE / VIRAL PROTEIN-HYDROLASE COMPLEX / VIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX