タイトル | Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2021年10月26日 (構造データの登録日) |
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著者 | Wu, X.-N. / Zhou, Q. / Huang, Y.-D. / Li, Z. / Wu, Y. / Luo, H.-B. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 2.50006900162 - 2.8 Å |
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構造データ | PDB-7vsl: Crystal structure of PDE8A catalytic domain in complex with 10 手法: X-RAY DIFFRACTION / 解像度: 2.50006900162 Å PDB-7vtv: Crystal structure of PDE8A catalytic domain in complex with 15 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-7vtw: Crystal structure of PDE8A catalytic domain in complex with 17 手法: X-RAY DIFFRACTION / 解像度: 2.79971328057 Å PDB-7vtx: Crystal structure of PDE8A catalytic domain in complex with 22 手法: X-RAY DIFFRACTION / 解像度: 2.50010936848 Å |
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化合物 | ChemComp-7XI: 2-chloro-9-(3-(2,2-difluoroethoxy)benzyl)-9H-purin-6-amine
ChemComp-7ZZ: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(difluoromethoxy)benzyl)-9H-purin-6-amine
ChemComp-807: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-isopropoxybenzyl)-9H-purin-6-amine
ChemComp-80D: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(pyridin-4-yl)benzyl)-9H-purin-6-amine
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由来 | - homo sapiens (ヒト)
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キーワード | HYDROLASE / cAMP-specific / Selective PDE8A inhibitor |
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