タイトル | Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP. |
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ジャーナル・号・ページ | Nat Commun, Vol. 13, Page 5834-5834, Year 2022 |
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掲載日 | 2022年2月26日 (構造データの登録日) |
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著者 | Schumacher, M.A. / Wormann, M.E. / Henderson, M. / Salinas, R. / Latoscha, A. / Al-Bassam, M.M. / Singh, K.S. / Barclay, E. / Gunka, K. / Tschowri, N. |
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リンク | Nat Commun / PubMed:36192422 |
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手法 | X線回折 |
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解像度 | 2.4 - 3.6 Å |
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構造データ | PDB-7u39: Structure of the apo form of Streptomyces venezuelae GlgX, the glycogen debranching enzyme 手法: X-RAY DIFFRACTION / 解像度: 3.51 Å PDB-7u3a: Structure of the Streptomyces venezuelae GlgX-c-di-GMP complex 手法: X-RAY DIFFRACTION / 解像度: 3.34 Å PDB-7u3b: Structure of S. venezuelae GlgX bound to c-di-GMP and acarbose (pH 8.5) 手法: X-RAY DIFFRACTION / 解像度: 3.6 Å PDB-7u3d: Structure of S. venezuelae GlgX-c-di-GMP-acarbose complex (4.6) 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å |
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化合物 | ChemComp-C2E: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) / c-di-GMP
ChemComp-A16: 4-O-(4,6-dideoxy-4-{[(1S,2S,3S,4R,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}-alpha-D-glucopyranosyl)-beta-D-glucopyranose
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由来 | - streptomyces venezuelae (バクテリア)
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キーワード | HYDROLASE / GlgX / glycogen debranching enzyme / glycogen / Streptomyces / c-di-GMP / development / apo form / second messenger / acarbose / Streptomyces development |
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