EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
ジャーナル・号・ページ	J. Biol. Chem., Vol. 298, Page 102127-102127, Year 2022
掲載日	2021年8月3日 (構造データの登録日)
著者	Mitchell, J.M. / June, C.M. / Baggett, V.L. / Lowe, B.C. / Ruble, J.F. / Bonomo, R.A. / Leonard, D.A. / Powers, R.A.
リンク	J. Biol. Chem. / PubMed:35709986
手法	X線回折
解像度	1.53 - 2.58 Å
構造データ	PDB-7rp8: X-ray crystal structure of OXA-24/40 K84D in complex with imipenem 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-7rp9: X-ray crystal structure of OXA-24/40 V130D in complex with imipenem 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-7rpa: X-ray crystal structure of OXA-24/40 K84D in complex with meropenem 手法: X-RAY DIFFRACTION / 解像度: 2.27 Å PDB-7rpb: X-ray crystal structure of OXA-24/40 V130D in complex with meropenem 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-7rpc: X-ray crystal structure of OXA-24/40 K84D in complex with ertapenem 手法: X-RAY DIFFRACTION / 解像度: 2.58 Å PDB-7rpd: X-ray crystal structure of OXA-24/40 V130D in complex with ertapenem 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7rpe: X-ray crystal structure of OXA-24/40 in complex with ertapenem 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-7rpf: X-ray crystal structure of OXA-24/40 in complex with doripenem 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7rpg: X-ray crystal structure of OXA-24/40 K84D in complex with cefotaxime 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å
化合物	ChemComp-ID1: Imipenem / 抗生剤YM ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-HOH: WATER ChemComp-HIW: (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca ChemComp-BCT: BICARBONATE ION / 炭酸水素アニオン / pH緩衝剤YM ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-MER: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d / 抗生剤YM ChemComp-6H7: (1S,4R,5S,6S)-3-{[(3S,5S)-5-carbamoylpyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid / (4R,5β)-3-[[(3S)-5β-カルバモイルピロリジン-3β-イル]チオ]-6β-[(R)-1-ヒドロキシエチ(以下略) / 薬剤, 抗生剤YM ChemComp-1RG: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid / 薬剤, 抗生剤YM ChemComp-4J6: (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid ChemComp-DRW: (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid ChemComp-CEF: CEFOTAXIME, C3' cleaved, open, bound form / 抗生剤YM
由来	acinetobacter baumannii (バクテリア)
キーワード	HYDROLASE/Inhibitor / acyl-enzyme complex / carbapenemase / HYDROLASE / HYDROLASE-Inhibitor complex / carbapenem