タイトル | Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. |
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ジャーナル・号・ページ | Commun Biol, Vol. 6, Page 450-450, Year 2023 |
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掲載日 | 2021年11月11日 (構造データの登録日) |
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著者 | Tusar, L. / Loboda, J. / Impens, F. / Sosnowski, P. / Van Quickelberghe, E. / Vidmar, R. / Demol, H. / Sedeyn, K. / Saelens, X. / Vizovisek, M. ...Tusar, L. / Loboda, J. / Impens, F. / Sosnowski, P. / Van Quickelberghe, E. / Vidmar, R. / Demol, H. / Sedeyn, K. / Saelens, X. / Vizovisek, M. / Mihelic, M. / Fonovic, M. / Horvat, J. / Kosec, G. / Turk, B. / Gevaert, K. / Turk, D. |
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リンク | Commun Biol / PubMed:37095140 |
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手法 | X線回折 |
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解像度 | 1.4 - 2.13 Å |
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構造データ | PDB-7q8d: Peptide TRESEDLE in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7q8f: Peptide GNYKEAKK in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.49 Å PDB-7q8g: Peptide ALAASS in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-7q8h: Peptide EVCKKKK in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7q8i: Peptide AVAEKQ in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-7q8j: Peptide IILKEK in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-7q8k: Peptide LLKVAL in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-7q8l: Peptide VPCGTAHE in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7q8m: Peptide KPKKKTK in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.57 Å PDB-7q8n: Peptide KKYDAFLA in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7q8o: Peptide LLSGKE in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7q8p: Peptide LLKVAL in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-7q8q: Peptide RLSAKP in complex with human cathepsin V C25S mutant 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-7q9c: Peptide RLSAKP in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7q9h: Peptide LLKAVAEKQ in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7qff: Peptide VACKSSQP in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-7qfh: Peptide AYFKKVL in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.52 Å PDB-7qhj: Peptide GAKSAA in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7qhk: Peptide QLRQQE in complex with human cathepsin V C25A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å |
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化合物 | |
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由来 | - homo sapiens (ヒト)
- synthetic construct (人工物)
- unidentified (未定義)
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キーワード | HYDROLASE / CathepsinV / Peptidyl substrate |
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