タイトル | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. |
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ジャーナル・号・ページ | Bioconjug. Chem., Vol. 33, Page 1210-1221, Year 2022 |
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掲載日 | 2021年9月13日 (構造データの登録日) |
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著者 | Bohnke, N. / Berger, M. / Griebenow, N. / Rottmann, A. / Erkelenz, M. / Hammer, S. / Berndt, S. / Gunther, J. / Wengner, A.M. / Stelte-Ludwig, B. ...Bohnke, N. / Berger, M. / Griebenow, N. / Rottmann, A. / Erkelenz, M. / Hammer, S. / Berndt, S. / Gunther, J. / Wengner, A.M. / Stelte-Ludwig, B. / Mahlert, C. / Greven, S. / Dietz, L. / Jorissen, H. / Barak, N. / Bomer, U. / Hillig, R.C. / Eberspaecher, U. / Weiske, J. / Giese, A. / Mumberg, D. / Nising, C.F. / Weinmann, H. / Sommer, A. |
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リンク | Bioconjug. Chem. / PubMed:35658441 |
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手法 | X線回折 |
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解像度 | 1.74 - 2.36 Å |
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構造データ | PDB-7ppe: CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 1 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-7ppf: CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 8 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-7ppg: CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 9 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-7pph: CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH Compound 10 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-7ppi: Crystal STRUCTURE OF NAMPT IN COMPLEX WITH Compound 11 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å |
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化合物 | ChemComp-7YK: N-[4-[(4R)-4-methyl-1-(oxan-4-yl)-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide
ChemComp-7YT: N-[4-[(4R)-1,4-dimethyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide
ChemComp-7YX: N-[4-[(4R)-1-cyclopentyl-4-methyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide
ChemComp-7YE: N-[4-[(5R)-6-oxidanylidene-5-quinolin-5-yl-5-(trifluoromethyl)-1,4-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide
ChemComp-7Z2: N-[4-[(5R)-1-(4-azanylbutyl)-6-oxidanylidene-5-quinolin-5-yl-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / SMALL MOLECULE INHIBITOR / NMPRTASE |
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