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-Structure paper
タイトル | Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 29, Issue 3, Page 190-193, Year 2022 |
掲載日 | 2022年3月10日 |
著者 | Alena Stsiapanava / Chenrui Xu / Shunsuke Nishio / Ling Han / Nao Yamakawa / Marta Carroni / Kathryn Tunyasuvunakool / John Jumper / Daniele de Sanctis / Bin Wu / Luca Jovine / |
PubMed 要旨 | Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 ...Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy. |
リンク | Nat Struct Mol Biol / PubMed:35273390 / PubMed Central |
手法 | EM (単粒子) / X線回折 |
解像度 | 1.35 - 7.4 Å |
構造データ | EMDB-13378, PDB-7pfp: EMDB-13794, PDB-7q3n: PDB-7p6r: PDB-7p6s: PDB-7p6t: |
化合物 | ChemComp-NAG: ChemComp-EDO: ChemComp-HOH: ChemComp-9JE: ChemComp-9D2: |
由来 |
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キーワード | ANTIMICROBIAL PROTEIN / Extracellular matrix / glycoprotein / N-glycan / structural protein / decoy module / D10C domain / D8C sequence / pancreas / intestine / mucosal immunity / FimH / AlphaFold / EGF DOMAIN / BETA-HAIRPIN / ZP MODULE / ZP DOMAIN / ZP-N DOMAIN / ZP-C DOMAIN / INTERDOMAIN LINKER / PROTEIN FILAMENT / PROTEIN POLYMERIZATION / D8C DOMAIN / HIGH-MANNOSE SUGAR / CELL ADHESION / BACTERIAL ADHESIN / TYPE I PILUS / SUGAR BINDING PROTEIN / LECTIN / URINARY TRACT INFECTION / UTI / UROPATHOGENIC E. COLI / UPEC |