タイトル | Structural and Mechanistic Insights into C-S Bond Formation in Gliotoxin. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 60, Page 14188-14194, Year 2021 |
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掲載日 | 2021年1月28日 (構造データの登録日) |
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著者 | Scherlach, K. / Kuttenlochner, W. / Scharf, D.H. / Brakhage, A.A. / Hertweck, C. / Groll, M. / Huber, E.M. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:33909314 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.65 Å |
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構造データ | PDB-7nc1: Glutathione-S-transferase GliG with partially disordered active site 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7nc2: Glutathione-S-transferase GliG (space group P3221) 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7nc3: Glutathione-S-transferase GliG (space group P212121) 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-7nc5: Glutathione-S-transferase GliG in complex with reduced glutathione 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7nc6: Glutathione-S-transferase GliG in complex with cyclo[L-Phe-L-Ser]-bis-glutathione-adduct 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-7nc8: Glutathione-S-transferase GliG mutant S24A 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7nc9: Glutathione-S-transferase GliG mutant H26N 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-7ncb: Glutathione-S-transferase GliG mutant H26A 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-7ncd: Glutathione-S-transferase GliG mutant N27D 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-7nce: Glutathione-S-transferase GliG mutant N27A 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7ncl: Glutathione-S-transferase GliG mutant E82Q 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7ncm: Glutathione-S-transferase GliG mutant E82A 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7ncn: Glutathione-S-transferase GliG mutant S83A 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7nco: Glutathione-S-transferase GliG mutant K127R 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7ncp: Glutathione-S-transferase GliG mutant K127A 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-7nct: Glutathione-S-transferase GliG mutant K127G 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-7ncu: Glutathione-S-transferase GliG mutant K127G in complex with oxidized glutathione 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å |
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化合物 | ChemComp-U8B: (2~{S})-2-azanyl-5-[[(2~{R})-3-[(2~{R},5~{R})-5-(hydroxymethyl)-3,6-bis(oxidanylidene)-2-(phenylmethyl)-5-sulfanyl-piperazin-2-yl]sulfanyl-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid
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由来 | ![](img/tx_fungus.gif) aspergillus fumigatus a1163 (カビ)![](img/tx_fungus.gif) neosartorya fumigata (strain cea10 / cbs 144.89 / fgsc a1163) (カビ)
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キーワード | BIOSYNTHETIC PROTEIN / Aspergillus fumigatus / mycotoxin / glutathione-S-transferase / carbon-sulphur-bond / epidithiodioxopiperazine |
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