タイトル | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2021年2月14日 (構造データの登録日) |
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著者 | Wang, Y. / Li, W. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 2.4 - 2.708 Å |
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構造データ | PDB-7e4p: Crystal structure of tubulin in complex with Ansamitocin P3 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7e4y: Crystal structure of tubulin in complex with L-DM4-SMe 手法: X-RAY DIFFRACTION / 解像度: 2.708 Å |
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化合物 | ChemComp-BKF: (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate
ChemComp-BKU: (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name)
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由来 | ![](img/tx_mammal.gif) bos taurus (ウシ)![](img/tx_mammal.gif) rattus norvegicus (ドブネズミ)![](img/tx_bird.gif) gallus gallus (ニワトリ)
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キーワード | STRUCTURAL PROTEIN/INHIBITOR / microtubule assembly inhibitors / STRUCTURAL PROTEIN-INHIBITOR complex |
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