| タイトル | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. |
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| ジャーナル・号・ページ | Elife, Vol. 11, Year 2022 |
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| 掲載日 | 2020年11月10日 (構造データの登録日) |
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 著者 | Wei, T. / Wang, J. / Liang, R. / Chen, W. / Chen, Y. / Ma, M. / He, A. / Du, Y. / Zhou, W. / Zhang, Z. ...Wei, T. / Wang, J. / Liang, R. / Chen, W. / Chen, Y. / Ma, M. / He, A. / Du, Y. / Zhou, W. / Zhang, Z. / Zeng, X. / Wang, C. / Lu, J. / Guo, X. / Chen, X.W. / Wang, Y. / Tian, R. / Xiao, J. / Lei, X. |
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 リンク | Elife / PubMed:35439114 |
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| 手法 | X線回折 |
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| 解像度 | 2.194 - 3.29 Å |
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| 構造データ | PDB-7dg4:
The co-crystal structure of DYRK2 with a small molecule inhibitor 6
手法: X-RAY DIFFRACTION / 解像度: 2.58 Å PDB-7dh9:
The co-crystal structure of DYRK2 with a small molecule inhibitor 7
手法: X-RAY DIFFRACTION / 解像度: 2.194 Å PDB-7dhc:
The co-crystal structure of DYRK2 with a small molecule inhibitor 10
手法: X-RAY DIFFRACTION / 解像度: 2.592 Å PDB-7dhh:
The co-crystal structure of DYRK2 with a small molecule inhibitor 19
手法: X-RAY DIFFRACTION / 解像度: 2.486 Å PDB-7dhk:
The co-crystal structure of DYRK2 with a small molecule inhibitor 13
手法: X-RAY DIFFRACTION / 解像度: 2.341 Å PDB-7dhn:
The co-crystal structure of DYRK2 with a small molecule inhibitor 20
手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-7dho:
The co-crystal structure of DYRK2 with a small molecule inhibitor 14
手法: X-RAY DIFFRACTION / 解像度: 3.29 Å PDB-7dhv:
The co-crystal structure of DYRK2 with a small molecule inhibitor 8
手法: X-RAY DIFFRACTION / 解像度: 2.679 Å PDB-7djo:
The co-crystal structure of DYRK2 with a small molecule inhibitor 17
手法: X-RAY DIFFRACTION / 解像度: 2.499 Å PDB-7dl6:
The co-crystal structure of DYRK2 with a small molecule inhibitor 18
手法: X-RAY DIFFRACTION / 解像度: 2.648 Å |
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| 化合物 | ChemComp-H5R:
2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine
ChemComp-H7F:
[2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol
ChemComp-H99:
4-[bis(fluoranyl)methyl]-2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine
ChemComp-H7L:
[9-(azetidin-3-ylmethylsulfanyl)-2,7-dimethoxy-acridin-4-yl]methanol
ChemComp-H7O:
2-methoxy-7-phenylmethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine
ChemComp-H7R:
7-methoxy-2-methylsulfanyl-9-(piperidin-4-ylmethylsulfanyl)-[1,3]thiazolo[5,4-b]quinoline
ChemComp-H7U:
2-methoxy-9-(piperidin-4-ylmethylsulfanyl)-7-propan-2-yloxy-acridine
ChemComp-H7X:
2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine-4-carboxylic acid
ChemComp-H80:
[2,7-dimethoxy-9-[[(3S)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol
ChemComp-H96:
[2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol
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| 由来 |   homo sapiens (ヒト)
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 キーワード | CELL CYCLE (細胞周期) / kinase (キナーゼ) / inhibitor (酵素阻害剤) |
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