タイトル Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. ジャーナル・号・ページ Molecules , Vol. 25, Year 2020掲載日 2020年10月15日 (構造データの登録日) 著者Zhang, B. / Pang, L. / Nautiyal, M. / De Graef, S. / Gadakh, B. / Lescrinier, E. / Rozenski, J. / Strelkov, S.V. / Weeks, S.D. / Van Aerschot, A. リンク Molecules / PubMed:33081246手法 X線回折 解像度 2 - 2.25 Å 構造データ PDB-7ap1 : 構造ビューア Klebsiella pneumoniae Seryl-tRNA synthetase in Complex with Compound SerS7HMDDA手法 : X-RAY DIFFRACTION / 解像度 : 2.18 Å
PDB-7ap2 : 構造ビューア Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound LeuS7HMDDA手法 : X-RAY DIFFRACTION / 解像度 : 2.25 Å
PDB-7ap3 : 構造ビューア Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA手法 : X-RAY DIFFRACTION / 解像度 : 2.0 Å
PDB-7ap4 : 構造ビューア Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA手法 : X-RAY DIFFRACTION / 解像度 : 2.15 Å
化合物 ChemComp-RUZ : 構造ビューア [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]sulfamate
ChemComp-RRW : 構造ビューア [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate
ChemComp-RRB : 構造ビューア [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate
ChemComp-RSN : 構造ビューア (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid
由来 klebsiella pneumoniae (肺炎桿菌)neisseria gonorrhoeae (淋菌)escherichia coli bl21(de3) (大腸菌)thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (バクテリア) キーワード LIGASE / protein-inhibitor complex / coiled-coil / tRNA synthetase / Rossmann fold / tRNA aminoacylation