タイトル | Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48 |
---|
ジャーナル・号・ページ | To Be Published |
---|
掲載日 | 2020年7月13日 (構造データの登録日) |
---|
著者 | Tassone, G. / Di Pisa, F. / Benvenuti, M. / De Luca, F. / Pozzi, C. / Docquier, J.D. / Mangani, S. |
---|
リンク | PubMedで検索 |
---|
手法 | X線回折 |
---|
解像度 | 1.6 - 1.94 Å |
---|
構造データ | PDB-6zrg: Crystal structure of OXA-10loop48 in complex with hydrolyzed doripenem 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-6zrh: Crystal structure of OXA-10loop24 in complex with ertapenem 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6zri: Crystal structure of OXA-10loop24 in complex with meropenem 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6zrj: Crystal structure of class D Beta-lactamase OXA-48 in complex with ertapenem 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-6zrp: Crystal structure of class D Beta-lactamase OXA-48 in complex with meropenem 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-6zw2: Crystal structure of OXA-10loop48 in complex with hydrolyzed meropenem 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å |
---|
化合物 | ChemComp-QP2: (4R,5S)-3-{[(3S,5S)-5-({[amino(dihydroxy)methyl]amino}methyl)pyrrolidin-3-yl]sulfanyl}-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
ChemComp-2RG: (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid / 薬剤, 抗生剤*YM
ChemComp-DWZ: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid / 抗生剤*YM
ChemComp-8YL: (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan / 抗生剤*YM
|
---|
由来 | - escherichia coli (大腸菌)
- klebsiella pneumoniae (肺炎桿菌)
|
---|
キーワード | HYDROLASE / Beta-lactamase / OXA-10loop48 / carbapenem / doripenem / OXA-10loop24 / ertapenem / acylenzyme / laboratory variant / meropenem / CHDL / OXA-48 |
---|