タイトル | Drugging all RAS isoforms with one pocket. |
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ジャーナル・号・ページ | Future Med Chem, Vol. 12, Page 1911-1923, Year 2020 |
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掲載日 | 2020年6月26日 (構造データの登録日) |
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著者 | Kessler, D. / Bergner, A. / Bottcher, J. / Fischer, G. / Dobel, S. / Hinkel, M. / Mullauer, B. / Weiss-Puxbaum, A. / McConnell, D.B. |
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リンク | Future Med Chem / PubMed:32779487 |
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手法 | X線回折 |
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解像度 | 1.55 - 2.031 Å |
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構造データ | PDB-6zio: CRYSTAL STRUCTURE OF NRAS (C118S) IN COMPLEX WITH GDP 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-6zir: CRYSTAL STRUCTURE OF NRAS (C118S) IN COMPLEX WITH GDP AND COMPOUND 18 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6ziz: CRYSTAL STRUCTURE OF NRAS Q61R IN COMPLEX WITH GTP AND COMPOUND 18 手法: X-RAY DIFFRACTION / 解像度: 1.785 Å PDB-6zj0: CRYSTAL STRUCTURE OF HRAS-G12D IN COMPLEX WITH GCP AND COMPOUND 18 手法: X-RAY DIFFRACTION / 解像度: 1.763 Å PDB-6zl3: CRYSTAL STRUCTURE OF HRAS IN COMPLEX WITH COMPOUND 18 and GDP 手法: X-RAY DIFFRACTION / 解像度: 2.031 Å PDB-6zl5: CRYSTAL STRUCTURE OF KRAS-G12D(C118S) IN COMPLEX WITH BI-2852 AND GDP 手法: X-RAY DIFFRACTION / 解像度: 1.645 Å PDB-6zli: CRYSTAL STRUCTURE OF KRAS-G12D IN COMPLEX WITH COMPOUND 13 AND GCP 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å |
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化合物 | ChemComp-EZZ: (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one
ChemComp-F0K: (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one
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由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE / GTPase |
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