タイトル | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. |
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ジャーナル・号・ページ | J Chem Theory Comput, Vol. 17, Page 1240-1249, Year 2021 |
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掲載日 | 2020年4月14日 (構造データの登録日) |
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著者 | Li, Y. / Bedi, R.K. / Wiedmer, L. / Sun, X. / Huang, D. / Caflisch, A. |
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リンク | J Chem Theory Comput / PubMed:33472367 |
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手法 | X線回折 |
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解像度 | 1.2 - 2.3 Å |
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構造データ | PDB-6ynn: Crystal structure of YTHDC1 with compound DHU_DC1_135 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-6yno: Crystal structure of YTHDC1 with compound DHU_DC1_139 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-6zcm: Crystal structure of YTHDC1 with compound DHU_DC1_180 手法: X-RAY DIFFRACTION / 解像度: 1.24 Å PDB-6zcn: Crystal structure of YTHDC1 with m6A 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6zd3: Crystal structure of YTHDC1 M438A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6zd4: Crystal structure of YTHDC1 S378A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-6zd5: Crystal structure of YTHDC1 S378A mutant complex with m6A 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6zd7: Crystal structure of YTHDC1 T379V mutant complex with m6A 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6zd8: Crystal structure of YTHDC1 T379V mutant 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6zd9: Crystal structure of YTHDC1 apo purified using GST tag 手法: X-RAY DIFFRACTION / 解像度: 1.51 Å PDB-6zda: Crystal structure of YTHDC1 M438A mutant complex with m6A 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å |
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化合物 | ChemComp-P0B: 6-[[(2-chloranyl-6-fluoranyl-phenyl)methyl-methyl-amino]methyl]-1~{H}-pyrimidine-2,4-dione
ChemComp-P0W: 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione
ChemComp-QF2: 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione
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由来 | - homo sapiens (ヒト)
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キーワード | RNA BINDING PROTEIN / YTHDC1 / m6A / complex / inhibitor |
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