タイトル | Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. |
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ジャーナル・号・ページ | Sci Rep, Vol. 10, Page 21964-21964, Year 2020 |
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掲載日 | 2020年4月28日 (構造データの登録日) |
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著者 | Chowdhury, R. / Abboud, M.I. / McAllister, T.E. / Banerji, B. / Bhushan, B. / Sorensen, J.L. / Kawamura, A. / Schofield, C.J. |
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リンク | Sci Rep / PubMed:33319810 |
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手法 | X線回折 |
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解像度 | 1.46 - 2.279 Å |
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構造データ | PDB-6yvw: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with monocyclic BB-328 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-6yvx: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic BB-287 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6yvz: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic JLS-367 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-6yw0: Lysine-N,N-Dimethylated HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with BB-287 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6yw1: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer) 手法: X-RAY DIFFRACTION / 解像度: 1.46 Å PDB-6yw2: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer) 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-6yw3: HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer) 手法: X-RAY DIFFRACTION / 解像度: 2.279 Å PDB-6yw4: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer) 手法: X-RAY DIFFRACTION / 解像度: 1.528 Å |
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化合物 | ChemComp-PW5: 4-[(5-bromanyl-4,6-dimethyl-pyridin-2-yl)amino]-4-oxidanylidene-butanoic acid
ChemComp-2JP: 4-(isoquinolin-3-ylamino)-4-oxobutanoic acid
ChemComp-PW8: 4-[(5-bromanylisoquinolin-3-yl)amino]-4-oxidanylidene-butanoic acid
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由来 | homo sapiens (ヒト)- synthetic construct (人工物)
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キーワード | OXIDOREDUCTASE / NON-HEME DIOXYGENASE / IRON / 2-OXOGLUTARATE / HYPOXIA-INDUCIBLE FACTOR / HIF / HIF PROLYL HYDROXYLASE DOMAIN 2 / PHD2 / EGLN1 / OXYGENASE / HYPOXIA / DNA-BINDING / METAL-BINDING / TRANSCRIPTION / HELIX-LOOP-HELIX-BETA / DSBH / FACIAL TRIAD / CYTOPLASM / TRANSCRIPTION/EPIGENETIC REGULATION / SIGNALING / DEVELOPMENT / CELL STRUCTURE / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / UBL CONJUGATION / POLYMORPHISM / VITAMIN C / ZINC-FINGER / FAMILIAL ERYTHROCYTOSIS / BREAST CANCER / TRANSCRIPTION COMPLEX |
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