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-Structure paper
タイトル | Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution. |
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ジャーナル・号・ページ | FEBS Lett, Vol. 594, Issue 21, Page 3551-3567, Year 2020 |
掲載日 | 2020年9月10日 |
著者 | Alexander Golubev / Bulat Fatkhullin / Iskander Khusainov / Lasse Jenner / Azat Gabdulkhakov / Shamil Validov / Gulnara Yusupova / Marat Yusupov / Konstantin Usachev / |
PubMed 要旨 | Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for ...Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for new drugs and treatments. As the majority of antibiotics target the ribosome, knowledge of its detailed structure is crucial for drug development. Here, we report the cryo-EM reconstruction at 3.2 Å resolution of the S. aureus ribosome with P-site tRNA, messenger RNA, and 10 RNA modification sites previously not assigned or visualized. The resulting model is the most precise and complete high-resolution structure to date of the S. aureus 70S ribosome with functional ligands. |
リンク | FEBS Lett / PubMed:32852796 |
手法 | EM (単粒子) |
解像度 | 3.2 Å |
構造データ | EMDB-10791, PDB-6yef: |
化合物 | ChemComp-MG: ChemComp-K: |
由来 |
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キーワード | RIBOSOME / rRNA modifications / 70S / initiation complex / S. aureus |