タイトル | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. |
---|
ジャーナル・号・ページ | Sci Adv, Vol. 6, Year 2020 |
---|
掲載日 | 2020年3月19日 (構造データの登録日) |
---|
著者 | Lolicato, M. / Natale, A.M. / Abderemane-Ali, F. / Crottes, D. / Capponi, S. / Duman, R. / Wagner, A. / Rosenberg, J.M. / Grabe, M. / Minor Jr., D.L. |
---|
リンク | Sci Adv / PubMed:33127683 |
---|
手法 | X線回折 |
---|
解像度 | 2.6 - 3.901 Å |
---|
構造データ | PDB-6w7b: K2P2.1 (TREK-1), 0 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.88 Å PDB-6w7c: K2P2.1 (TREK-1), 1 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.4 Å PDB-6w7d: K2P2.1 (TREK-1), 10 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å PDB-6w7e: K2P2.1 (TREK-1), 30 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.29 Å PDB-6w82: K2P2.1 (TREK-1), 50 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.6 Å PDB-6w83: K2P2.1 (TREK-1), 100 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.901 Å PDB-6w84: K2P2.1 (TREK-1), 200 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.7 Å PDB-6w85: K2P2.1 (TREK-1):ML335 complex, 200 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.8 Å PDB-6w86: K2P2.1 (TREK-1):ML335 complex, 100 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.299 Å PDB-6w87: K2P2.1 (TREK-1):ML335 complex, 50 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-6w88: K2P2.1 (TREK-1):ML335 complex, 30 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-6w8a: K2P2.1 (TREK-1):ML335 complex, 10 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.002 Å PDB-6w8c: K2P2.1 (TREK-1):ML335 complex, 1 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6w8f: K2P2.1 (TREK-1):ML335 complex, 0 mM K+ 手法: X-RAY DIFFRACTION / 解像度: 3.4 Å |
---|
化合物 | ChemComp-PIO: [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate / 1-O-(1-O,2-O-ジオクタノイル-L-グリセロ-3-ホスホ)-D-myo-イノシト-ル4,5-ビスりん酸
ChemComp-Q6F: N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
ChemComp-IEP: [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate
|
---|
由来 | - mus musculus (ハツカネズミ)
|
---|
キーワード | METAL TRANSPORT / ion channel / K2P / TREK1 / TREK-1 |
---|