タイトル | Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 59, Page 11273-11277, Year 2020 |
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掲載日 | 2019年8月6日 (構造データの登録日) |
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著者 | White, A.M. / de Veer, S.J. / Wu, G. / Harvey, P.J. / Yap, K. / King, G.J. / Swedberg, J.E. / Wang, C.K. / Law, R.H.P. / Durek, T. / Craik, D.J. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:32270580 |
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手法 | X線回折 / NMR (溶液) |
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解像度 | 1.398 - 2.3467 Å |
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構造データ | PDB-6q1u: Structure of plasmin and peptide complex 手法: X-RAY DIFFRACTION / 解像度: 2.3467 Å PDB-6u22: Crystal structure of SFTI-triazole inhibitor in complex with beta-trypsin 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-6u24: NMR solution structure of triazole bridged SFTI-1 手法: SOLUTION NMR PDB-6u7q: NMR solution structure of SFTI-R10 手法: SOLUTION NMR PDB-6u7r: NMR solution structure of SFTI1 based KLK7 protease inhibitor 手法: SOLUTION NMR PDB-6u7s: NMR solution structure of SFTI-1 based plasmin inhibitor 手法: SOLUTION NMR PDB-6u7u: NMR solution structure of triazole bridged matriptase inhibitor 手法: SOLUTION NMR PDB-6u7w: NMR solution structure of a triazole bridged KLK7 inhibitor 手法: SOLUTION NMR PDB-6u7x: NMR solution structure of triazole bridged plasmin inhibitor 手法: SOLUTION NMR PDB-6vxy: Triazole bridged SFTI1 inhibitor in complex with beta-trypsin 手法: X-RAY DIFFRACTION / 解像度: 1.398 Å PDB-6vy8: NMR solution structure of a triazole bridged trypsin inhibitor based on the framework of SFTI-1 手法: SOLUTION NMR |
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化合物 | |
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由来 | homo sapiens (ヒト)![](img/tx_plant.gif) helianthus annuus (ヒグルマ)![](img/tx_mammal.gif) bos taurus (ウシ)
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キーワード | BLOOD CLOTTING / serine protease / cyclic peptide / complex / antifibrinolysis / HYDROLASE/INHIBITOR / Triazole / Peptidomimetic / BIOSYNTHETIC PROTEIN / HYDROLASE-INHIBITOR complex / Disulfide mimetic / Inhibitor / KLK7 inhibitor / Plasmin inhibitor |
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