EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
ジャーナル・号・ページ	Thesis, Year 2019
掲載日	2019年3月12日 (構造データの登録日)
著者	Petrick, J.K. / Jahnke, W.
リンク	Thesis / PubMedで検索
手法	X線回折
解像度	1.28 - 2.6 Å
構造データ	PDB-6r04: T. cruzi FPPS 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-6r05: T. CRUZI FPPS IN COMPLEX WITH N-BENZYL-6-METHYLPYRIDIN-2-AMINE 手法: X-RAY DIFFRACTION / 解像度: 1.57 Å PDB-6r06: T. CRUZI FPPS IN COMPLEX WITH (3S,4S)-4-(3,4-dimethylphenoxy)-1-(prop-2-yn-1-yl)piperidin-3-ol 手法: X-RAY DIFFRACTION / 解像度: 1.559 Å PDB-6r07: T. cruzi FPPS in complex with 2-(5-chlorobenzo[b]thiophen-3-yl)acetic acid 手法: X-RAY DIFFRACTION / 解像度: 1.57 Å PDB-6r08: T. cruzi FPPS in complex with 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å PDB-6r09: T. cruzi FPPS in complex with 2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)benzo[d]thiazole 手法: X-RAY DIFFRACTION / 解像度: 1.28 Å PDB-6r0a: T. cruzi FPPS in complex with 3-((4-(benzo[d]thiazol-2-yl)piperazin-1-yl)methyl)-1H-indol-5-ol 手法: X-RAY DIFFRACTION / 解像度: 1.32 Å PDB-6r0b: T. cruzi FPPS in complex with 3-((4-(5-chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)methyl)-1H-indol-5-ol 手法: X-RAY DIFFRACTION / 解像度: 1.612 Å PDB-6r39: T. brucei FPPS in complex with 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6shv: T. cruzi FPPS in complex with 5-(4-fluorophenoxy)pyridin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 1.808 Å PDB-6si5: T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one 手法: X-RAY DIFFRACTION / 解像度: 2.097 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-ACT: ACETATE ION / 酢酸イオン ChemComp-HOH: WATER ChemComp-JNE: 6-methyl-~{N}-(phenylmethyl)pyridin-2-amine / (6-メチル-2-ピリジル)ベンジルアミン ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-JMN: (3~{S},4~{S})-4-(3,4-dimethylphenoxy)-1-prop-2-ynyl-piperidin-3-ol ChemComp-3N2: (5-chloro-1-benzothiophen-3-yl)acetic acid / 5-クロロベンゾ[b]チオフェン-3-酢酸 ChemComp-GO1: 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid ChemComp-JMK: 2-[4-(1~{H}-indol-3-ylmethyl)piperazin-1-yl]-1,3-benzothiazole ChemComp-JMT: 3-[[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]methyl]-1~{H}-indol-5-ol ChemComp-JMW: 3-[[4-(5-chloranyl-1,3-benzothiazol-2-yl)piperazin-1-yl]methyl]-1~{H}-indol-5-ol ChemComp-BFH: 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid ChemComp-LDW: 5-(4-fluoranylphenoxy)pyridin-2-amine ChemComp-LEQ*: 5-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylcarbonyl)-1-methyl-pyridin-2-one
由来	trypanosoma cruzi (トリパノソーマ) trypanosoma brucei (トリパノソーマ)
キーワード	TRANSFERASE / farnesyl diphosphate synthase / sterol biosynthesis / farnesyl pyrophosphate / homodimer / Trypanosoma brucei