タイトル | Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). |
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ジャーナル・号・ページ | Biochem. J., Vol. 476, Page 875-887, Year 2019 |
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掲載日 | 2018年12月19日 (構造データの登録日) |
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著者 | Chaikuad, A. / Koschade, S.E. / Stolz, A. / Zivkovic, K. / Pohl, C. / Shaid, S. / Ren, H. / Lambert, L.J. / Cosford, N.D.P. / Brandts, C.H. / Knapp, S. |
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リンク | Biochem. J. / PubMed:30782972 |
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手法 | X線回折 |
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解像度 | 1.75 - 2.77 Å |
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構造データ | PDB-6qas: Crystal structure of ULK1 in complexed with PF-03814735 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6qat: Crystal structure of ULK2 in complexed with hesperadin 手法: X-RAY DIFFRACTION / 解像度: 2.77 Å PDB-6qau: Crystal structure of ULK2 in complexed with MRT67307 手法: X-RAY DIFFRACTION / 解像度: 2.48 Å PDB-6qav: Crystal structure of ULK2 in complexed with MRT68921 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å |
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化合物 | ChemComp-34W: N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide
ChemComp-FE7: N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide / ヘスペラジン / 阻害剤*YM
ChemComp-1FV: N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide
ChemComp-HVH: ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / ULK1 / autophagy / ATG1 / kinase / inhibitor complex / Structural Genomics / Structural Genomics Consortium / SGC / ULK2 |
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