タイトル | Chemical logic of MraY inhibition by antibacterial nucleoside natural products. |
---|
ジャーナル・号・ページ | Nat Commun, Vol. 10, Page 2917-2917, Year 2019 |
---|
掲載日 | 2019年5月14日 (構造データの登録日) |
---|
著者 | Mashalidis, E.H. / Kaeser, B. / Terasawa, Y. / Katsuyama, A. / Kwon, D.Y. / Lee, K. / Hong, J. / Ichikawa, S. / Lee, S.Y. |
---|
リンク | Nat Commun / PubMed:31266949 |
---|
手法 | X線回折 |
---|
解像度 | 2.95 - 3.7 Å |
---|
構造データ | PDB-6oyh: Crystal structure of MraY bound to carbacaprazamycin 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å PDB-6oyz: Crystal structure of MraY bound to capuramycin 手法: X-RAY DIFFRACTION / 解像度: 3.62 Å PDB-6oz6: Crystal structure of MraY bound to 3'-hydroxymureidomycin A 手法: X-RAY DIFFRACTION / 解像度: 3.7 Å |
---|
化合物 | ChemComp-NK4: (5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-heptadecyl-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine
ChemComp-NKM: (2~{S},3~{S},4~{S})-2-[(1~{R})-2-azanyl-1-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-methoxy-4-oxidanyl-oxolan-2-yl]-2-oxidanylidene-ethoxy]-3,4-bis(oxidanyl)-~{N}-[(3~{S})-2-oxidanylideneazepan-3-yl]-3,4-dihydro-2~{H}-pyran-6-carboxamide / カプラマイシン
ChemComp-NKD: (2~{S})-2-[[(2~{S})-1-[[(2~{S},3~{S})-3-[[(2~{S})-2-azanyl-3-(3-hydroxyphenyl)propanoyl]-methyl-amino]-1-[[(~{Z})-[(3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-ylidene]methyl]amino]-1-oxidanylidene-butan-2-yl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]carbamoylamino]-3-(3-hydroxyphenyl)propanoic acid
|
---|
由来 | - lama glama (ラマ)
- aquifex aeolicus (strain vf5) (バクテリア)
|
---|
キーワード | MEMBRANE PROTEIN/TRANSFERASE / peptidoglycan biosynthesis / antibiotic target / integral membrane enzyme / translocase / MEMBRANE PROTEIN / MEMBRANE PROTEIN-TRANSFERASE complex |
---|