タイトル | Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. |
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ジャーナル・号・ページ | Acs Infect Dis., Vol. 5, Page 1013-1021, Year 2019 |
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掲載日 | 2018年8月16日 (構造データの登録日) |
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著者 | Torelli, N.J. / Akhtar, A. / DeFrees, K. / Jaishankar, P. / Pemberton, O.A. / Zhang, X. / Johnson, C. / Renslo, A.R. / Chen, Y. |
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リンク | Acs Infect Dis. / PubMed:30942078 |
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手法 | X線回折 |
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解像度 | 1.15 - 2.202 Å |
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構造データ | PDB-6efj: Crystal structure of NDM-1 with compound 9 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-6m7i: Crystal structure of KPC-2 with compound 3 手法: X-RAY DIFFRACTION / 解像度: 1.701 Å PDB-6md8: Crystal structure of CTX-M-14 with compound 3 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-6mdu: Crystal structure of NDM-1 with compound 7 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-6mey: Crystal structure of KPC-2 with compound 9 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-6mia: Crystal structure of CTX-M-14 with compound 6 手法: X-RAY DIFFRACTION / 解像度: 1.399 Å PDB-6mll: Crystal structure of KPC-2 with compound 7 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-6mnp: Crystal structure of KPC-2 with compound 6 手法: X-RAY DIFFRACTION / 解像度: 2.202 Å |
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化合物 | ChemComp-O5E: (2R)-2-phenyl-2-(phenylamino)-N-(1H-tetrazol-5-yl)acetamide
ChemComp-J84: 1-(2,4-dichlorophenyl)-4-(1H-tetrazol-5-yl)-1H-pyrazol-5-amine
ChemComp-N1G: 1,5-diphenyl-N-(1H-tetrazol-5-yl)-1H-pyrazole-3-carboxamide
ChemComp-1CE: 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
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由来 | klebsiella pneumoniae (肺炎桿菌)![](img/tx_bacteria.gif) escherichia coli (大腸菌)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Carbapenemase / tetrazole / inhibitor / complex / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE/INHIBITOR / HYDROLASE-INHIBITOR complex / Extended spectrum beta-lactamase / EXBLs |
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