タイトル | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. |
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ジャーナル・号・ページ | Nat Commun, Vol. 10, Page 1402-1402, Year 2019 |
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掲載日 | 2018年8月22日 (構造データの登録日) |
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著者 | Simonetta, K.R. / Taygerly, J. / Boyle, K. / Basham, S.E. / Padovani, C. / Lou, Y. / Cummins, T.J. / Yung, S.L. / von Soly, S.K. / Kayser, F. ...Simonetta, K.R. / Taygerly, J. / Boyle, K. / Basham, S.E. / Padovani, C. / Lou, Y. / Cummins, T.J. / Yung, S.L. / von Soly, S.K. / Kayser, F. / Kuriyan, J. / Rape, M. / Cardozo, M. / Gallop, M.A. / Bence, N.F. / Barsanti, P.A. / Saha, A. |
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リンク | Nat Commun / PubMed:30926793 |
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手法 | X線回折 |
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解像度 | 2.05 - 2.7 Å |
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構造データ | PDB-6m90: Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-6m91: Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-6m92: Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-6m93: Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-6m94: Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å |
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化合物 | ChemComp-J91: 2-(2-fluorophenoxy)-3-{[2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid
ChemComp-J97: 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid
ChemComp-J8V: 3-{[2-oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid
ChemComp-J8Y: 2-oxo-N-[3-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide
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由来 | homo sapiens (ヒト)
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キーワード | LIGASE / Ubiquitin Molecular Glue Enhancer |
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