タイトル | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. |
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ジャーナル・号・ページ | Commun Biol, Vol. 4, Page 280-280, Year 2021 |
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掲載日 | 2019年11月20日 (構造データの登録日) |
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著者 | Lin, H.Y. / Chen, C.Y. / Lin, T.C. / Yeh, L.F. / Hsieh, W.C. / Gao, S. / Burnouf, P.A. / Chen, B.M. / Hsieh, T.J. / Dashnyam, P. ...Lin, H.Y. / Chen, C.Y. / Lin, T.C. / Yeh, L.F. / Hsieh, W.C. / Gao, S. / Burnouf, P.A. / Chen, B.M. / Hsieh, T.J. / Dashnyam, P. / Kuo, Y.H. / Tu, Z. / Roffler, S.R. / Lin, C.H. |
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リンク | Commun Biol / PubMed:33664385 |
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手法 | X線回折 |
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解像度 | 1.651 - 3.188 Å |
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構造データ | PDB-6ld0: Structure of Bifidobacterium dentium beta-glucuronidase complexed with C6-hexyl uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 1.901 Å PDB-6ld6: Structure of Bifidobacterium dentium beta-glucuronidase 手法: X-RAY DIFFRACTION / 解像度: 2.204 Å PDB-6ldb: Structure of Bifidobacterium dentium beta-glucuronidase complexed with uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 1.651 Å PDB-6ldc: Structure of Bifidobacterium dentium beta-glucuronidase complexed with C6-nonyl uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 2.181 Å PDB-6ldd: Structure of Bifidobacterium dentium beta-glucuronidase complexed with C6-propyl uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 2.205 Å PDB-6leg: Structure of E. coli beta-glucuronidase complex with uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 2.603 Å PDB-6lej: Structure of E. coli beta-glucuronidase complex with C6-propyl uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 2.617 Å PDB-6lel: Structure of E. coli beta-glucuronidase complex with C6-hexyl uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 2.498 Å PDB-6lem: Structure of E. coli beta-glucuronidase complex with C6-nonyl uronic isofagomine 手法: X-RAY DIFFRACTION / 解像度: 3.188 Å |
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化合物 | ChemComp-E8X: (2~{S},3~{S},4~{R},5~{R})-2-hexyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid
ChemComp-E9O: (2~{S},3~{S},4~{R},5~{R})-2-nonyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid
ChemComp-CKX: (2~{S},3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-2-propyl-piperidine-3-carboxylic acid
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由来 | - bifidobacterium dentium (strain atcc 27534 / dsm 20436 / jcm 1195 / bd1) (バクテリア)
- escherichia coli (大腸菌)
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キーワード | CARBOHYDRATE / inhibitor / complex / glycosidase / HYDROLASE / isofagomine |
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