タイトル | Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. |
---|
ジャーナル・号・ページ | Biochem. Biophys. Res. Commun., Vol. 511, Page 800-805, Year 2019 |
---|
掲載日 | 2016年9月14日 (構造データの登録日) |
---|
著者 | Zhang, L. / Ko, T.-P. / Malwal, S.R. / Liu, W. / Zhou, S. / Yu, X. / Oldfield, E. / Guo, R.-T. / Chen, C.-C. |
---|
リンク | Biochem. Biophys. Res. Commun. / PubMed:30837154 |
---|
手法 | X線回折 |
---|
解像度 | 2.23 - 2.4 Å |
---|
構造データ | PDB-5gwv: Structure of MoeN5-Sso7d fusion protein in complex with a substrate analogue 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5gww: Structure of MoeN5-Sso7d fusion protein in complex with a permethylated substrate analogue 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6j8v: Structure of MOEN5-SSO7D fusion protein in complex with ligand 2 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-6j8w: Structure of MOEN5-SSO7D fusion protein in complex with lig 1 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å |
---|
化合物 | ChemComp-78S: (2R)-3-dimethoxyphosphoryloxy-2-[(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoic acid
ChemComp-7B5: methyl (2R)-3-dimethoxyphosphoryloxy-2-[(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoate
ChemComp-C0X: (2S)-3-dimethoxyphosphoryloxy-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoic acid
|
---|
由来 | streptomyces ghanaensis (バクテリア)![](img/tx_archaea.gif) sulfolobus solfataricus (strain atcc 35092 / dsm 1617 / jcm 11322 / p2) (古細菌)![](img/tx_archaea.gif) sulfolobus solfataricus (古細菌)
|
---|
キーワード | TRANSFERASE / DNA BINDING PROTEIN / moenomycin / antibiotics / biosynthesis / prenyl transferase / alpha helical / ALPHA |
---|