EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
ジャーナル・号・ページ	J. Med. Chem., Vol. 61, Page 7560-7572, Year 2018
掲載日	2017年9月19日 (構造データの登録日)
著者	Czarna, A. / Wang, J. / Zelencova, D. / Liu, Y. / Deng, X. / Choi, H.G. / Zhang, T. / Zhou, W. / Chang, J.W. / Kildalsen, H. ...Czarna, A. / Wang, J. / Zelencova, D. / Liu, Y. / Deng, X. / Choi, H.G. / Zhang, T. / Zhou, W. / Chang, J.W. / Kildalsen, H. / Seternes, O.M. / Gray, N.S. / Engh, R.A. / Rothweiler, U.
リンク	J. Med. Chem. / PubMed:30095246
手法	X線回折
解像度	2.22 - 2.88 Å
構造データ	PDB-6eif: DYRK1A in complex with XMD7-117 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-6eij: DYRK1A in complex with HG-8-60-1 手法: X-RAY DIFFRACTION / 解像度: 2.42 Å PDB-6eil: DYRK1A in complex with XMD8-49 手法: X-RAY DIFFRACTION / 解像度: 2.465 Å PDB-6eip: DYRK1A in complex with XMD8-62e 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-6eiq: DYRK1A in complex with XMD14-124 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6eir: DYRK1A in complex with XMD15-27-2 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-6eis: DYRK1A in complex with JWC-055 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-6eiv: DYRK1A in complex with JWD-065 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-6ej4: DYRK1A in complex with XMD7-112 手法: X-RAY DIFFRACTION / 解像度: 2.88 Å
化合物	ChemComp-B5T: 4-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide ChemComp-HOH: WATER ChemComp-B5Z: ~{N}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide ChemComp-B6B: [3-azanyl-6-(5-azanyl-2-methoxy-phenyl)pyrazin-2-yl]-pyridin-3-yl-methanone ChemComp-B7B: 4-[[(3~{R},7~{S})-2-cyclopentyl-9-methyl-8-oxidanylidene-2,9,12,14-tetrazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),10,12-trien-13-yl]amino]benzamide ChemComp-B6Z: [4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]-phenyl-methanone ChemComp-B6H: ~{N}-[4-[[4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide ChemComp-B6N: 1-[4-fluoranyl-2-(trifluoromethyl)phenyl]-9-(1~{H}-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-one ChemComp-B6Q: ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide ChemComp-B7W: 3-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)aniline
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / Dual specificity tyrosine-phosphorylation-regulated kinase 1A