タイトル | Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. |
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ジャーナル・号・ページ | Nature, Vol. 566, Page 259-263, Year 2019 |
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掲載日 | 2018年8月2日 (構造データの登録日) |
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著者 | Eaglesham, J.B. / Pan, Y. / Kupper, T.S. / Kranzusch, P.J. |
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リンク | Nature / PubMed:30728498 |
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手法 | X線回折 |
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解像度 | 1.703 - 2.6 Å |
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構造データ | PDB-6ea6: Structure of VACV poxin 2'3' cGAMP-specific nuclease 手法: X-RAY DIFFRACTION / 解像度: 1.703 Å PDB-6ea8: Structure of VACV poxin in pre-reactive state with nonhydrolyzable 2'3' cGAMP 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6ea9: Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3'] 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-J2A: (2S,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-disulfanyloctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione
ChemComp-J2B: O-[(1R,2R,3R)-5-{[(S)-{[(2R,3R,4R,5R)-2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydro
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由来 | - vaccinia virus wr (ウイルス)
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キーワード | HYDROLASE / Vaccina virus / nuclease / cGAS / cGAMP / poxvirus / innate immunity |
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