タイトル | Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors |
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ジャーナル・号・ページ | Nat Commun, Vol. 10, Page 321-, Year 2019 |
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掲載日 | 2018年7月27日 (構造データの登録日) |
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著者 | Regan, M.C. / Zhu, Z. / Yuan, H. / Myers, S.J. / Menaldino, D.S. / Tahirovic, Y.A. / Liotta, D.C. / Traynelis, S.F. / Furukawa, H. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 2.1 - 2.72 Å |
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構造データ | PDB-6e7r: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-4 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6e7s: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-6e7t: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-6 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-6e7u: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-31 手法: X-RAY DIFFRACTION / 解像度: 2.27 Å PDB-6e7v: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-88 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6e7w: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-115 手法: X-RAY DIFFRACTION / 解像度: 2.67 Å PDB-6e7x: Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-97 手法: X-RAY DIFFRACTION / 解像度: 2.58 Å |
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化合物 | ChemComp-HYS: N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
ChemComp-HZ4: N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](ethyl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
ChemComp-HYY: N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](propyl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
ChemComp-HX7: N-{4-[(2S)-3-{butyl[2-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
ChemComp-T88: N-{4-[(2R)-3-{butyl[2-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
ChemComp-HXM: N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](propan-2-yl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
ChemComp-T97: N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](2-methylpropyl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide
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由来 | - xenopus laevis (アフリカツメガエル)
- rattus norvegicus (ドブネズミ)
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キーワード | TRANSPORT PROTEIN / NMDA Receptor / Ion channel / Allosteric modulation / Extracellular domain |
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