タイトル | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. |
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ジャーナル・号・ページ | Elife, Vol. 7, Year 2018 |
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掲載日 | 2018年1月1日 (構造データの登録日) |
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著者 | Yang, Y. / Kang, D. / Nguyen, L.A. / Smithline, Z.B. / Pannecouque, C. / Zhan, P. / Liu, X. / Steitz, T.A. |
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リンク | Elife / PubMed:30044217 |
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手法 | X線回折 |
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解像度 | 1.901 - 2.225 Å |
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構造データ | PDB-6c0j: Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6c0k: Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 手法: X-RAY DIFFRACTION / 解像度: 1.958 Å PDB-6c0l: Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6c0n: Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-6c0o: Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 1.901 Å PDB-6c0p: Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-6c0r: Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 2.049 Å PDB-6cgf: Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-6duf: Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 1.963 Å PDB-6dug: Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 2.225 Å PDB-6duh: Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a 手法: X-RAY DIFFRACTION / 解像度: 2.003 Å |
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化合物 | |
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由来 | - human immunodeficiency virus type 1 group m subtype b (ヒト免疫不全ウイルス)
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キーワード | REPLICATION / non-nucleoside inhibitor / HIV-1 reverse transcriptase |
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