EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
ジャーナル・号・ページ	J. Med. Chem., Vol. 61, Page 8875-8894, Year 2018
掲載日	2018年4月19日 (構造データの登録日)
著者	Hodges, T.R. / Abbott, J.R. / Little, A.J. / Sarkar, D. / Salovich, J.M. / Howes, J.E. / Akan, D.T. / Sai, J. / Arnold, A.L. / Browning, C. ...Hodges, T.R. / Abbott, J.R. / Little, A.J. / Sarkar, D. / Salovich, J.M. / Howes, J.E. / Akan, D.T. / Sai, J. / Arnold, A.L. / Browning, C. / Burns, M.C. / Sobolik, T. / Sun, Q. / Beesetty, Y. / Coker, J.A. / Scharn, D. / Stadtmueller, H. / Rossanese, O.W. / Phan, J. / Waterson, A.G. / McConnell, D.B. / Fesik, S.W.
リンク	J. Med. Chem. / PubMed:30205005
手法	X線回折
解像度	1.68 - 2.478 Å
構造データ	PDB-6d55: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.68 Å PDB-6d56: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.68 Å PDB-6d59: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6d5e: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6d5g: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6d5h: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6d5j: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.751 Å PDB-6d5l: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6d5m: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 2.081 Å PDB-6d5v: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 2.04 Å PDB-6d5w: Ras:SOS:Ras in complex with a small molecule activator 手法: X-RAY DIFFRACTION / 解像度: 2.478 Å
化合物	ChemComp-GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / Gpp(NH)p / GppNHp, GMPPNP, エネルギー貯蔵分子類似体YM ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-FWA: 6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)-1H-benzimidazole ChemComp-FMT: FORMIC ACID / ギ酸 ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-HOH: WATER ChemComp-FVM: 6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-benzimidazole ChemComp-FVJ: 6-chloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole ChemComp-CL: Unknown entry / クロリド ChemComp-FVG: 1-[(2S)-1-{6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazol-4-yl}pyrrolidin-2-yl]methanamine ChemComp-FVD: 6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-4-(1,2,3,6-tetrahydropyridin-4-yl)-1H-benzimidazole ChemComp-BME: BETA-MERCAPTOETHANOL / 2-メルカプトエタノ-ル ChemComp-FV7: 6-chloro-4-(2-chlorophenyl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole ChemComp-FV4: 6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole ChemComp-FW7: 6-chloro-1-[(3-chloro-4-fluorophenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole ChemComp-FW4: 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-(piperazin-1-yl)-1H-benzimidazole ChemComp-FVY: 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-1H-benzimidazol-2-amine ChemComp-FVV*: 10-[(4-fluorophenyl)methyl]-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole
由来	homo sapiens (ヒト)
キーワード	SIGNALING PROTEIN / Ras / SOS / inhibitor / ONCOPROTEIN / Protein-protein complex / MAPK