タイトル | Modifications to a common phosphorylation network provide individualized control in caspases. |
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ジャーナル・号・ページ | J. Biol. Chem., Vol. 293, Page 5447-5461, Year 2018 |
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掲載日 | 2017年10月24日 (構造データの登録日) |
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著者 | Thomas, M.E. / Grinshpon, R. / Swartz, P. / Clark, A.C. |
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リンク | J. Biol. Chem. / PubMed:29414778 |
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手法 | X線回折 |
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解像度 | 1.54 - 2.16 Å |
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構造データ | PDB-6bdv: Crystal structure of Caspase 3 S150A 手法: X-RAY DIFFRACTION / 解像度: 1.938 Å PDB-6bfj: Caspase-3 Mutant - T245D,S249D 手法: X-RAY DIFFRACTION / 解像度: 1.543 Å PDB-6bfk: Caspase-3 Mutant- T245A 手法: X-RAY DIFFRACTION / 解像度: 1.753 Å PDB-6bfl: Caspase-3 Mutant- D9A,D28A,T245D 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6bfo: Caspase-3 Mutant- T245D 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-6bg0: Caspase-3 Mutant - D9A,D28A,S150D 手法: X-RAY DIFFRACTION / 解像度: 2.125 Å PDB-6bg1: Caspase-3 Mutant - D9A,D28A,S150E 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6bg4: Caspase-3 Mutant- T152D 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6bgk: Caspase-3 Mutant- D9A,D28A,T152D 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6bgq: Caspase-3 Mutant - S150D 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-6bgr: Caspase-3 Mutant - S150E 手法: X-RAY DIFFRACTION / 解像度: 2.16 Å PDB-6bgs: Caspase-3 Mutant - S150Y 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6bh9: Caspase-3 Mutant - T152A 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-6bha: Caspase-3 Mutant - T152V 手法: X-RAY DIFFRACTION / 解像度: 1.603 Å |
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化合物 | |
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由来 | homo sapiens (ヒト)- synthetic construct (人工物)
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キーワード | APOPTOSIS / allosteric regulation / biophysics / caspase / computational biology / fluorescence / molecular dynamics / protein evolution / apoptosis/inhibitor / allosteric regulation; apoptosis; biophysics; caspase; computational biology; X-ray crystallography; fluorescence; molecular dynamics; protein evolution / apoptosis-inhibitor complex |
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