タイトル | Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 115, Page E2819-E2828, Year 2018 |
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掲載日 | 2017年8月16日 (構造データの登録日) |
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著者 | Kalas, V. / Hibbing, M.E. / Maddirala, A.R. / Chugani, R. / Pinkner, J.S. / Mydock-McGrane, L.K. / Conover, M.S. / Janetka, J.W. / Hultgren, S.J. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:29507247 |
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手法 | X線回折 |
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解像度 | 1.2 - 2.101 Å |
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構造データ | PDB-6aow: Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6aox: F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with TF antigen 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6aoy: F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-nitrophenyl beta-galactoside (ONPG) 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6arm: F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-nitrophenyl beta-galactoside (ONPG) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6arn: F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-methoxyphenyl beta-galactoside (OMPG) 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6aro: F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with 8-hydroxyquinoline beta-galactoside 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-6as8: F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with ortho-biphenyl-2'-carboxyl N-acetyl-beta-galactosaminoside 手法: X-RAY DIFFRACTION / 解像度: 2.101 Å |
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化合物 | ChemComp-BQY: 2-methoxyphenyl beta-D-galactopyranoside
ChemComp-BTG: ortho-biphenyl-2'-carboxyl N-acetyl-beta-galactosaminoside
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由来 | - escherichia coli (大腸菌)
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キーワード | SUGAR BINDING PROTEIN / Fimbrial adhesin / lectin / bacterial adhesion |
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