タイトル | Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus. |
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ジャーナル・号・ページ | ACS Infect Dis, Vol. 4, Page 175-184, Year 2018 |
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掲載日 | 2017年8月18日 (構造データの登録日) |
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著者 | Paparella, A.S. / Lee, K.J. / Hayes, A.J. / Feng, J. / Feng, Z. / Cini, D. / Deshmukh, S. / Booker, G.W. / Wilce, M.C.J. / Polyak, S.W. / Abell, A.D. |
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リンク | ACS Infect Dis / PubMed:29131575 |
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手法 | X線回折 |
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解像度 | 2.4 - 2.71 Å |
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構造データ | PDB-6apw: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.614 Å PDB-6aqq: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.71 Å PDB-8eni: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å |
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化合物 | ChemComp-BTV: 4-[(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)methyl]benzoic acid
ChemComp-BVY: (3aS,4S,6aR)-4-(5-{1-[(3-fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
ChemComp-WNE: 3-[4-(5-fluoro-4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-5-methyl-1,3-benzoxazol-2(3H)-one
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由来 | ![](img/tx_bacteria.gif) staphylococcus aureus (黄色ブドウ球菌) staphylococcus aureus subsp. aureus mu50 (黄色ブドウ球菌)
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キーワード | LIGASE / Inhibitor / Antibiotic / LIGASE/LIGASE INHIBITOR / Biotin protein ligase / DNA BINDING PROTEIN / LIGASE-LIGASE INHIBITOR complex |
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