タイトル | Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 60, Page 10231-10244, Year 2017 |
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掲載日 | 2017年9月15日 (構造データの登録日) |
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著者 | Liu, Q. / Huang, F. / Yuan, X. / Wang, K. / Zou, Y. / Shen, J. / Xu, Y. |
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リンク | J. Med. Chem. / PubMed:29193967 |
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手法 | X線回折 |
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解像度 | 1.805 - 2.312 Å |
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構造データ | PDB-5ye7: The crystal structure of Lp-PLA2 in complex with a novel inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.312 Å PDB-5ye8: The crystal structure of Lp-PLA2 in complex with a novel inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.851 Å PDB-5ye9: The crystal structure of Lp-PLA2 in complex with a novel inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.876 Å PDB-5yea: The crystal structure of Lp-PLA2 in complex with a novel inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.805 Å |
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化合物 | ChemComp-8U0: N-[4-[(4-naphthalen-2-yloxyphenyl)sulfamoyl]phenyl]ethanamide
ChemComp-8U3: N-[3,4-bis(fluoranyl)phenyl]methanesulfonamide
ChemComp-8U6: N-[4-[(3-cyano-4-naphthalen-2-yloxy-phenyl)sulfamoyl]phenyl]ethanamide
ChemComp-8U9: 4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3-cyano-phenyl]sulfamoyl]benzoic acid
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由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / hydrolase inhibitor / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |
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