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-Structure paper
タイトル | Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D. |
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ジャーナル・号・ページ | Medchemcomm, Vol. 8, Page 1196-1206, Year 2017 |
掲載日 | 2017年2月22日 (構造データの登録日) |
![]() | Low, J.D. / Bartberger, M.D. / Chen, K. / Cheng, Y. / Fielden, M.R. / Gore, V. / Hickman, D. / Liu, Q. / Allen Sickmier, E. / Vargas, H.M. ...Low, J.D. / Bartberger, M.D. / Chen, K. / Cheng, Y. / Fielden, M.R. / Gore, V. / Hickman, D. / Liu, Q. / Allen Sickmier, E. / Vargas, H.M. / Werner, J. / White, R.D. / Whittington, D.A. / Wood, S. / Minatti, A.E. |
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手法 | X線回折 |
解像度 | 1.9 - 2.805 Å |
構造データ | ![]() PDB-5ux4: ![]() PDB-5uyu: |
化合物 | ![]() ChemComp-NAG: ![]() ChemComp-3UT: ![]() ChemComp-HOH: ![]() ChemComp-IOD: ![]() ChemComp-8QV: ![]() ChemComp-GOL: |
由来 |
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![]() | HYDROLASE / Cathepsin D / Beta Amyloid Cleaving Enzyme / BACE1 / aspartic protease / Alzheimers disease / APP / amyloid precursor protein |