タイトル | Resistance to Enediyne Antitumor Antibiotics by Sequestration. |
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ジャーナル・号・ページ | Cell Chem Biol, Vol. 25, Page 1075-1085.e4, Year 2018 |
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掲載日 | 2017年1月29日 (構造データの登録日) |
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著者 | Chang, C.Y. / Yan, X. / Crnovcic, I. / Annaval, T. / Chang, C. / Nocek, B. / Rudolf, J.D. / Yang, D. / Babnigg, G. / Joachimiak, A. ...Chang, C.Y. / Yan, X. / Crnovcic, I. / Annaval, T. / Chang, C. / Nocek, B. / Rudolf, J.D. / Yang, D. / Babnigg, G. / Joachimiak, A. / Phillips Jr., G.N. / Shen, B. |
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リンク | Cell Chem Biol / PubMed:29937405 |
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手法 | X線回折 |
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解像度 | 1.08 - 2.27 Å |
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構造データ | PDB-5ump: Crystal structure of TnmS3, an antibiotic binding protein from Streptomyces sp. CB03234 手法: X-RAY DIFFRACTION / 解像度: 1.08 Å PDB-5umq: Crystal structure of TnmS1, an antibiotic binding protein from Streptomyces sp. CB03234 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5umw: Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234 手法: X-RAY DIFFRACTION / 解像度: 2.27 Å PDB-5umx: Crystal structure of TnmS3 in complex with riboflavin 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-5umy: Crystal structure of TnmS3 in complex with tiancimycin 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-6bbx: Crystal structure of TnmS3 in complex with TNM C 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-TNN: (1aS,11S,11aR,14Z,18R)-3,8,18-trihydroxy-11a-[(1R)-1-hydroxyethyl]-7-methoxy-11,11a-dihydro-4H-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinoline-4,9(10H)-dione
ChemComp-D77: methyl (2R,3R)-2,3-dihydroxy-3-[(1aS,11S,11aR,14Z,18R)-3,7,8,18-tetrahydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]butanoate
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由来 | streptomyces sp. cb03234 (バクテリア)
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キーワード | Tiancimycin-binding protein / glyoxalase/bleomycin resistance protein/dioxygenase superfamily / Structural Genomics / PSI-2 / Protein Structure Initiative / Midwest Center for Structural Genomics / MCSG / Enzyme Discovery for Natural Product Biosynthesis / NatPro / PSI-Biology / LYASE |
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