タイトル | Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. |
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ジャーナル・号・ページ | Viruses, Vol. 10, Year 2018 |
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掲載日 | 2017年5月5日 (構造データの登録日) |
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著者 | Pokorna, J. / Pachl, P. / Karlukova, E. / Hejdanek, J. / Rezacova, P. / Machara, A. / Hudlicky, J. / Konvalinka, J. / Kozisek, M. |
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リンク | Viruses / PubMed:29933553 |
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手法 | X線回折 |
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解像度 | 1.36 - 2 Å |
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構造データ | PDB-5nwe: Complex of H275Y mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5nz4: Complex of I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-5nze: Complex of S247N mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 1.69 Å PDB-5nzf: Complex of H275Y/I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-5nzn: Complex of H275Y/S247N mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å |
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化合物 | ChemComp-G39: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid / オセルタミビルカルボキシラ-ト / 薬剤, 抗ウイルス剤*YM
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由来 | - influenza a virus (A型インフルエンザウイルス)
- unidentified influenza virus (インフルエンザウイルス)
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キーワード | HYDROLASE / neuraminidase / influenza / complex / inhibitor / VIRAL PROTEIN |
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