タイトル | Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 59, Page 9567-9573, Year 2016 |
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掲載日 | 2016年9月27日 (構造データの登録日) |
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著者 | Halland, N. / Czech, J. / Czechtizky, W. / Evers, A. / Follmann, M. / Kohlmann, M. / Schreuder, H.A. / Kallus, C. |
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リンク | J. Med. Chem. / PubMed:27749053 |
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手法 | X線回折 |
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解像度 | 1.64 - 2.02 Å |
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構造データ | PDB-5lyd: Crystal structure of 1 in complex with tafCPB 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-5lyf: Crystal structure of 1 in complex with tafCPB 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-5lyi: Crystal structure of 1 in complex with tafCPB 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-5lyl: Crystal structure of 1 in complex with tafCPB 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å |
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化合物 | ChemComp-7B0: (2~{S})-6-azanyl-2-(sulfamoylamino)hexanoic acid
ChemComp-7B6: (2~{S})-6-azanyl-2-[[(2~{R})-1-[[(1~{R},2~{S},4~{S})-2-bicyclo[2.2.1]heptanyl]amino]-3-cyclohexyl-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid
ChemComp-T4F: (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]hepta
ChemComp-T5F: (2~{S})-2-[[(2~{S})-1-(1-adamantylamino)-3-cyclohexyl-1-oxidanylidene-propan-2-yl]sulfamoylamino]-6-azanyl-hexanoic acid
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由来 | - sus scrofa (ブタ)
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キーワード | HYDROLASE / tafinized carboxypeptidase B / HYRDROLASE |
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