タイトル | Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 4727-4732, Year 2017 |
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掲載日 | 2015年7月31日 (構造データの登録日) |
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著者 | Newton, M.S. / Guo, X. / Soderholm, A. / Nasvall, J. / Lundstrom, P. / Andersson, D.I. / Selmer, M. / Patrick, W.M. |
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リンク | Proc. Natl. Acad. Sci. U.S.A. / PubMed:28416687 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.65 Å |
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構造データ | PDB-5ab3: S.enterica HisA mutant D7N, D10G, dup13-15, Q24L, G102A 手法: X-RAY DIFFRACTION / 解像度: 1.803 Å PDB-5ac7: S. enterica HisA with mutations D7N, D10G, dup13-15 手法: X-RAY DIFFRACTION / 解像度: 1.904 Å PDB-5ac8: S. enterica HisA with mutations D10G, dup13-15, G102A 手法: X-RAY DIFFRACTION / 解像度: 1.699 Å PDB-5g1t: S. enterica HisA mutant dup13-15, D10G 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5g1y: S. enterica HisA mutant D10G, dup13-15,V14:2M, Q24L, G102 手法: X-RAY DIFFRACTION / 解像度: 1.798 Å PDB-5g2h: S. enterica HisA with mutation L169R 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5g2i: S. enterica HisA mutant Dup13-15(VVR) 手法: X-RAY DIFFRACTION / 解像度: 1.601 Å PDB-5g2w: S. enterica HisA mutant D10G, G102A 手法: X-RAY DIFFRACTION / 解像度: 2.099 Å PDB-5g4e: S. enterica HisA mutant D10G, Dup13-15, Q24L, G102A, V106L 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-5g4w: S. enterica HisA mutant D7N, D10G, Dup13-15 (VVR) with substrate ProFAR 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5g5i: S. enterica HisA mutant D10G 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-5l6u: S. ENTERICA HISA MUTANT - D10G, DUP13-15, Q24L, G102A 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5l9f: S. enterica HisA mutant - D10G, G11D, dup13-15, G44E, G102A 手法: X-RAY DIFFRACTION / 解像度: 2.594 Å |
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化合物 | ChemComp-2ER: [(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL DIHYDROGEN PHOSPHATE / ホスホリブロシルホルムイミノ-AICAR-りん酸
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
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由来 | - salmonella enterica subsp. enterica serovar cubana str. 76814 (サルモネラ菌)
- salmonella enterica (サルモネラ菌)
- salmonella choleraesuis (サルモネラ菌)
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キーワード | ISOMERASE / HISA / PROTEIN EVOLUTION / IAD MODEL / TRPF |
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