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-Structure paper
タイトル | Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 60, Page 1142-1150, Year 2017 |
掲載日 | 2016年4月4日 (構造データの登録日) |
![]() | Tso, S.C. / Lou, M. / Wu, C.Y. / Gui, W.J. / Chuang, J.L. / Morlock, L.K. / Williams, N.S. / Wynn, R.M. / Qi, X. / Chuang, D.T. |
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手法 | X線回折 |
解像度 | 1.65 - 2.045 Å |
構造データ | ![]() PDB-5j6a: ![]() PDB-5j71: |
化合物 | ![]() ChemComp-P46: ![]() ChemComp-HOH: ![]() ChemComp-TLA: ![]() ChemComp-P35: |
由来 |
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![]() | Transferase/Transferase Inhibitor / GHKL protein kinase / pyruvate dehydrogenase complex / Mitochondrial protein kinases / Impaired glucose oxidation / Hepatic steatosis / Type 2 diabetes / Cancer / Bergerat nucleotide-binding fold / protein kinase / Transferase-Transferase Inhibitor complex |