EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
ジャーナル・号・ページ	J. Med. Chem., Vol. 59, Page 8787-8803, Year 2016
掲載日	2016年1月24日 (構造データの登録日)
著者	Myrianthopoulos, V. / Gaboriaud-Kolar, N. / Tallant, C. / Hall, M.L. / Grigoriou, S. / Brownlee, P.M. / Fedorov, O. / Rogers, C. / Heidenreich, D. / Wanior, M. ...Myrianthopoulos, V. / Gaboriaud-Kolar, N. / Tallant, C. / Hall, M.L. / Grigoriou, S. / Brownlee, P.M. / Fedorov, O. / Rogers, C. / Heidenreich, D. / Wanior, M. / Drosos, N. / Mexia, N. / Savitsky, P. / Bagratuni, T. / Kastritis, E. / Terpos, E. / Filippakopoulos, P. / Muller, S. / Skaltsounis, A.L. / Downs, J.A. / Knapp, S. / Mikros, E.
リンク	J. Med. Chem. / PubMed:27617704
手法	X線回折
解像度	1.7 - 2.4 Å
構造データ	PDB-5hrv: Crystal structure of the fifth bromodomain of human PB1 in complex with 1-ethylisochromeno[3,4-c]pyrazol-5(2H)-one) compound 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5hrw: Crystal structure of the fifth bromodomain of human PB1 in complex with 1-propylisochromeno[3,4-c]pyrazol-5(2H)-one) compound 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5hrx: Crystal structure of the fifth bromodomain of human PB1 in complex with 1-butylisochromeno[3,4-c]pyrazol-5(2H)-one) compound 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-5ii1: Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 1-methylisochromeno[3,4-c]pyrazol-5(3H)-one 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-5ii2: Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5iid: Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å
化合物	ChemComp-64C: 1-ethylisochromeno[3,4-c]pyrazol-5(3H)-one ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-64E: 1-propylisochromeno[3,4-c]pyrazol-5(3H)-one ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-64F: 1-butylisochromeno[3,4-c]pyrazol-5(3H)-one ChemComp-6BL: 1-methyl[2]benzopyrano[3,4-c]pyrazol-5(3H)-one ChemComp-K: Unknown entry / カリウムカチオン ChemComp-CIT: CITRIC ACID / クエン酸 ChemComp-LU2: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one / ルテオリン ChemComp-6BK: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one / 3′,4′,5-トリヒドロキシフラボン
由来	homo sapiens (ヒト)
キーワード	TRANSCRIPTION / BRM1 / BRG1-associated factor 180 / chromatin remodeling / PBRM1 / bromodomain / complex / small molecule / structural genomics consortium / SGC