タイトル | Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. |
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ジャーナル・号・ページ | Nat Commun, Vol. 7, Page 10912-10912, Year 2016 |
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掲載日 | 2015年4月27日 (構造データの登録日) |
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著者 | Langendorf, C.G. / Ngoei, K.R. / Scott, J.W. / Ling, N.X. / Issa, S.M. / Gorman, M.A. / Parker, M.W. / Sakamoto, K. / Oakhill, J.S. / Kemp, B.E. |
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リンク | Nat Commun / PubMed:26952388 |
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手法 | X線回折 |
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解像度 | 2.99 Å |
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構造データ | PDB-4zhx: Novel binding site for allosteric activation of AMPK 手法: X-RAY DIFFRACTION / 解像度: 2.99 Å PDB-5ezv: X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid) 手法: X-RAY DIFFRACTION / 解像度: 2.99 Å |
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化合物 | ChemComp-4O7: (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 / 抗がん剤, 抗真菌剤, 抗生剤, alkaloid*YM
ChemComp-C1V: 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile / A-769662
ChemComp-C2Z: 5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / serine/threonine kinase / allosteric activation / nucleotide-binding |
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