タイトル | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 138, Page 7244-7247, Year 2016 |
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掲載日 | 2015年11月1日 (構造データの登録日) |
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著者 | Song, H.G. / Dong, C. / Qin, M.M. / Chen, Y.Z. / Sun, Y.R. / Liu, J.J. / Chan, W. / Guo, Z.H. |
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リンク | J. Am. Chem. Soc. / PubMed:27213829 |
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手法 | X線回折 |
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解像度 | 1.34 - 2.3 Å |
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構造データ | PDB-5ej4: EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 15 min 手法: X-RAY DIFFRACTION / 解像度: 1.773 Å PDB-5ej5: EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 1.5 h 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5ej6: EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2min then soaked with isochorismate for 2 min 手法: X-RAY DIFFRACTION / 解像度: 2.243 Å PDB-5ej7: EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 21 s 手法: X-RAY DIFFRACTION / 解像度: 1.56 Å PDB-5ej8: EcMenD-ThDP-Mn2+ complex structure soaked with 2-ketoglutarate for 2 min 手法: X-RAY DIFFRACTION / 解像度: 1.34 Å PDB-5ej9: EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-5eja: EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7 min 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
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化合物 | ChemComp-TD6: (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid
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由来 | - escherichia coli k12 (大腸菌)
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キーワード | TRANSFERASE / Post-decarboxylation intermediate |
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